RNA Polymerase as a Target in Drug Discovery

Guest Speaker: Dr. Arkady Mustaev
Public Health Research Institute
Newark, New Jersey

Abstract:
Transcription of genetic information encoded in DNA is one of the major cellular process that constitute the essence of life. The major player  of transcription is  RNA polymerase - the enzyme which copies genes in the form of RNA that serves as a template for protein biosynthesis. The presentation will address the basic principle of the enzyme's functioning revealed in the course of multi disciplinary studies carried out in the lab as well as the consideration of RNAP as a therapeutic target in chemotherapy of numerous infectious diseases.

Brief Biography:
Dr Mustaev graduated from Novosibirsk State University (Department of Chemistry) in 1978. He received Ph.D. from Novosibirsk Institute of Bioorganic Chemistry. Moved to United States in 1992. His major research interest is the molecular mechanisms of transcription as well as search and development of new antibacterial drugs.

Seminar Series Coordinators:
Dr. Zeyuan Qiu       Zeyuan.qiu@njit.edu              973-596-5357
Dr. Sergiu Gorun    Sergiu.m.gorun@njit.edu       973-569-6595