Education

PhD Massachusetts Institute of Technology
MA Columbia University

Research Interests

• Bioinspired Artificial Enzymes: rational design, structures, catalysis, biomedical and materials science applications
• Structural Isotope Effects

Selected Recent Publications

"Biological and Biomimetic Catalysis of Manganese Redox Enzymes and their Models", J. Wikaira, S. M. Gorun Bioinorganic Catalysis, 2nd ed., J. Reedijk, Ed., M. Dekker, Inc., NY, 1999

"Structure and Reactivity of Iron and Manganese Methane Monooxygenase Models" Z. Hu, S. M. Gorun, Biomimetic Oxidations, B. Meunier, Ed., World Scientific, London, 2000.

"Re-engineering Enzyme-Model Active Sites: Reversible Binding of Dioxygen at Ambient Conditions by a Bioinspired Copper Complex" Z. Hu, R. D. Williams, D. Tran, T. G. Spiro, S. M. Gorun J. Am. Chem. Soc., 122, 3556, 2000.

"Copper-Based Bioinspired Oxygenation and Glyoxalase-like Reactivity" D. Diaconu, Z. Hu, S. M. Gorun J. Am. Chem. Soc., 124, 1564, 2002.

"Introduction of Bulky Perfluoroalkyl Groups at the Periphery of Zinc Perfluoro Phthalocyanine: Chemical, Structural, Electronic, and Preliminary Photophysical and Biological Effects" B. A. Bench, A. Beveridge, W. M. Sharman, G. J. Diebold,  J. E. van Lier, S. M. Gorun Angew. Chem. Int. Ed., 41, 748, 2002.

"Synthesis and Structure of a Bi-concave Perfluoro Cobalt Phthalocyanine and its Catalysis of Novel Oxidative Carbon-Phosphorus Bonds Formation using Air"  B. A. Bench, W. W. Brennessel, H.-J. Lee, S. M. Gorun Angew. Chem. Int. Ed., 41, 751, 2002.

"Deuterium Structural Effects in Inorganic and Bioinorganic Aggregates" J. Lee, N. Dennis Chasteen, G. Zhao, G. C. Papaefthymiou, S. M. Gorun J. Am. Chem. Soc., 124, 3042, 2002.

"Compositional and Isotopomer-Induced Phase Differentiation in Supramolecular Aggregates" J. Lee, S. M. Gorun  Angew. Chem. Int. Ed., 42, 1512, 2003.

"Spectroscopy and Electronic Structure of Electron Deficient Zinc Phthalocyanines" S. P. Keizer, W. J. Han, J. Mack, B. A. Bench, S. M. Gorun, M. J. Stillman J.  Am. Chem. Soc., 125, 7067, 2003.

"Evaluation of Photodynamic Therapy Agents through Transient Grating Measurements" A. C. Beveridge, B. A. Bench, S. M. Gorun, G. J. Diebold J. Phys. Chem. A, 107, 5138, 2003.

"Reengineering of organic-based metal active sites for oxidations and oxygenations" S. M. Gorun, in Activation and Functionalization of C-H Bonds, K. I. Goldberg and A. S. Goldman, Eds., Oxford University Press, pp. 407-422, 2004.

"Effects of Peripheral Substituents and Axial Ligands on the Electronic Structure and Properties of Iron Phthalocyanine" M.-S. Liao, T. Kar, S. M. Gorun, S. Scheiner Inorg. Chem., 43, 7151, 2004.

"Effects of Peripheral Substituents on the Electronic Structure and Properties of Unligated and Ligated Metal Phthalocyanines, Metal = Fe, Co, Zn." M.-S. Liao, J. D. Watts; M.-J, Huang, S. M. Gorun, T. Kar, S. Scheiner J. Chem. Theory Comput., 1, 1201, 2005

"Enhanced Acidity, Photophysical Properties and Liposome Binding of Perfluoroalkylated Phthalocyanines Lacking C-H Bonds" R. Minnes, C. Weitman, H.-J. Lee, S. M. Gorun, B. Ehrenberg Photochem.  Photobiol.  in the press.