Education

PhD, Rutgers University, Newark
MS, New Jersey Institute of Technology

Research Interest

Characterization of interactions between biological macromolecules (proteins and nucleic acids), and small ligand molecules, such as drugs and toxins. Application of spectroscopic and computational techniques to the investigation of intermolecular interactions. Identification of structural features of molecules responsible for biological activity. Application of rapid prototyping techniques for the construction of unique molecular models designed as research and teaching tools.

 
Selected Publications

"Conformational Analysis of Methylphenidate: Comparison of Molecular Orbital and Molecular Mechanics Methods", K.M. Gilbert, W.J. Skawinski, M. Misra, K.A. Paris, N.H. Naik, R.A. Buono, H.M. Deutsch, and C.A. Venanzi, Journal of Computer-Aided Molecular Design, 18, 719-738 (2004).

"A Molecular Orbital Study of Tambjamine E", W.J. Skawinski, T.J. Venanzi, and C.A. Venanzi, Journal of Physical Chemistry A, 108, 4542-4550 (2004).

"¹H and ¹³C NMR Structural Studies of Amiloride in Cryosolvents", W.J. Skawinski, A. Ofsievich, and C.A. Venanzi, Structural Chemistry, 13, 73-80 (2002).

“Nature of Intercalator Amiloride-Nucleobase Stacking.  An Empirical Potential and Ab Initio Electron Correlation Study”, D. Bondarev, W.J. Skawinski, and C.A. Venanzi, Journal of Physical Chemistry B, 104, 815-822 (2000).

"Molecular Models by Laser Stereolithography", C.A. Venanzi, W.J. Skawinski, and A.D. Ofsievich, in Physical Supramolecular Chemistry, L. Echegoyen and A. Kaifer, Eds., Kluwer, Dordrecht, The Netherlands, 1996, pp.127-142.

"From Maps to Models: A Concerted Computational Approach to Analysis of the Structure-Activity Relationships of Amiloride Analogues", C.A. Venanzi, R.A. Buono, W.J. Skawinski, T.J. Busanic, T.J. Venanzi, R.J. Zauhar, and V.B. Luzhkov, in: Computer-Aided Design of Agrochemicals, Pharmaceuticals and Materials, C.H. Reynolds, M.K. Holloway and H.K. Cox, Eds., ACS Symposium Series 589, American Chemical Society, Washington, D.C., 1995, pp. 51-63.

"The Application of Stereolithography to the Fabrication of Accurate Molecular Models", W.J. Skawinski, T.J. Busanic, A.D. Ofsievich, T.J. Venanzi, V.B. Luzhkov, and C.A. Venanzi, Journal of Molecular Graphics, 13, 126-135 (1995).

"Computer Modeling of Phenyl Acetate Hydrolysis in Water and in Reaction with ß-Cyclodextrin: Molecular Orbital Calculations with the Semiempirical AM1 Method and the Langevin Dipole Solvent Model", V.B. Luzhkov and C.A. Venanzi, Journal of Physical Chemistry, 99, 2312-2323 (1995).

"The Use of Laser Stereolithography to Produce Three-Dimensional Tactile Molecular Models for Blind and Visually-Impaired Scientists and Students", W.J. Skawinski, T.J. Busanic, A.D. Ofsievich, T.J. Venanzi, V.B. Luzhkov, and C.A. Venanzi, Information Technology and Disabilities, 1, no. 4, article 6, 1994.

“Labelling of tyrosines in proteins with [¹⁵N]tetranitromethane, a new NMR reporter for nitrotyrosines”, W.J. Skawinski, F. Adebodun, J.T. Cheng, F. Jordan, and R. Mendelsohn, Biochimica et Biophysica Acta, 1162, 297-308 (1993).

“Preparation of [¹⁵N]-labelled Tetranitromethane C(15NO2)4”, W.J. Skawinski, J. Flisak, A.C. Chung, F. Jordan, and R. Mendelsohn, Journal of Labelled Compounds and Radiopharmaceuticals, 28, 1179-1183 (1990).

“Hearing is Believing: The Modified Spectroscope”, L.V. Hinchliffe and W.J. Skawinski, The Science Teacher, 50, 53-55 (1983).