Haidong Huang

Contact Info

Email: haidong.huang@njit.edu
Office: 370 Tiernan Hall
Phone: 973-596-3576
Dept: Chemistry and Environmental Science

About Me


  • Ph.D 2006, State University of New York at Stony Brook
  • BS 2000, Peking University, China

Research Interests

  • Using artificial receptors to detect damaged DNA bases.
  • Using synthetic analogues to study mutagenic effect of DNA alkylation.
  • Artificial ribonucleases.

Selected Publications

1.    Zixing Zhuang, Rui Pan, Qian Zhang, Haidong Huang, Molecular Recognition of Pyrimidines by Triplex DNA Receptors. Bioorg. Med. Chem. Lett. 2015, 25, 1520-1524.

2.    Haidong Huang, Peter C. Tlatelpa. Tuning the Selectivity of Triplex DNA Receptors. Chem. Commun. 2015, 51, 5337-5339.

3.    Peter C. Tlatelpa, Haidong Huang. Stability of Pyrimidine N-glycosydic Bonds in the Presence of Lawesson’s Reagents: Revisit of 2-Thiolation of Pyrimidine Nucleosides. Tetrahedron Lett. 2014, 55, 4780-4784.

4.    Jagruti Rana, Haidong Huang, Actions of the Klenow Fragment of DNA Polymerase I and Some DNA Glycosylases on Chemically Stable Analogues of N7-methyl-2’-deoxyguanosine. Bioorg. Med. Chem. 2013, 21, 6886-6892.

5.    Qian Zhang, Yiqi Wang, Xianyang Meng, Rik Dhar, Haidong Huang, Triple-stranded DNA Containing 8-Oxo-7,8-dihydro-2’-deoxyguanosine: Implication in the Design of Selective 8-Oxo-7,8-dihydroguanine Aptamer Sensors. Anal. Chem. 2013, 85, 201-207.

6.    Sejal Patel, Jagruti Rana, Jyoti Roy, Haidong Huang, Cleavage of Pyrene-stabilized RNA Bulge Loop by Cyclohexane-1,2-diamine. Chem. Cen. J. 2012, 6:3.

7.    Jyoti Roy, Payal Chirania, Sanniv Ganguly, Haidong Huang, A DNA Aptamer Sensor for 8-Oxo-7,8-dihydroguanine. Bioorg. Med. Chem. Lett., 2012, 22, 863-867.

8.    Mayurbhai Patel, Avishek Dutta, Haidong Huang, A Selective Adenosine Sensor Derived from a Triplex DNA Aptamer. Anal. Bioanal. Chem. 2011, 400, 3035-3040.

9.    Haidong Huang, Shuhei Imoto, Marc M. Greenberg, The Mutagenicity of Thymine Glycol in E. coli Is Increased When It Is Part of a Tandem Lesion. Biochemistry 2009, 48, 7833-7841.

10.  Haidong Huang, James T. Stivers, Marc M. Greenberg, Competitive Inhibition of Uracil DNA Glycosylase by a Modified Nucleotide Whose Triphosphate Is a Substrate for DNA Polymerase. J. Am. Chem. Soc. 2009, 131, 1344-1345.

11.  Haidong Huang, Marc M. Greenberg, Hydrogen Bonding Contributes to the Selectivity of Nucleotide Incorporation Opposite an Oxidized Abasic Lesion by DNA Polymerases. J. Am. Chem. Soc. 2008, 130, 6080-6081.

12.  Haidong Huang, Marc M. Greenberg, Synthesis and Analysis of Oligonucleotides Containing Abasic Site Analogues. J. Org. Chem. 2008, 73, 2695-2703.

13.  Haidong Huang, Dale G. Drueckhammer, A Modular Molecular Tweezer Designed Using CAVEAT, Chem. Commun. 2006, 2995-2997.

14.  Haidong Huang, Dale G. Drueckhammer, A Computer-Designed Macrocyclic Zinc Receptor, Chem. Commun. 2005, 5196-5198.

15.  Jin Xun, Haidong Huang, Kurt W. Vogel, Dale Drueckhammer, The Importance of the Amide Bond Nearest the Thiol Group in Enzymatic Reactions of Coenzyme A, Bioorg. Chem. 2005, 33, 90-107.